Human Health

Human Health training modules

Human health modules are designed to explore the different issues associated with the interpretation and review of toxicological data in the context of regulatory requirements. Examples of difficult substances and difficult studies are presented, in conjunction with proposed strategies for successful data handling. The content and the level of detail presented in each module can be tailored to suit individual business needs.

Basic mammalian toxicology

The principles of toxicology in the context of hazard assessment are explored. The basics of toxicology, its regulatory data requirements and the interpretation of studies are covered in this module. Where do we start and what are we aiming for in regulatory toxicology?

Advanced mammalian toxicology

Building on the ‘Basic mammalian toxicology’ module, a more in depth analysis of toxicological data assessment is provided by exploring where difficulties may lie in data interpretation through case studies. During the course we provide examples of difficult substances and how to achieve a hazard assessment under these circumstances.

Genotoxicology

The module covers methodology and data interpretation in genotoxicology within the regulatory context.

Understanding CLP - Health

The Classification and Labelling of a substance is a requirement under most regulations. Here we explore how to derive C&L for human health properties along with basic understanding of human health hazard assessment.

Human exposure to chemicals - basics

Basic (Tier 1) models for qualitative and quantitative exposure of workers, professional and consumers are described and demonstrated. The basis for deriving exposure concentrations is explained.

Human exposure to chemicals - advanced

The weaknesses of Tier 1 models are discussed, and higher Tier models introduced, explained and exemplified.  However, more complex models may not always improve exposure assessment.  A critical discussion of available models is provided.

Basic risk characterisation - health

What data are required to conduct a risk characterisation? How do we gather the information and how does it translate into human health risk characterisation? The data requirements are explained and available models for conducting the assessment are presented.

Advanced risk characterisation - health

The approaches used to calculate Derived No-Effect Levels (DNELs) are reviewed, along with higher Tier exposure models. If risks are unacceptable, what are the next steps?  Can monitoring help? Is a higher level of control the only solution?